meningitis - Gram-negatieve staven (bv. Escherichia coli of Klebsiella spp.)
Advices
| Priority | Medication | Remarks |
|---|---|---|
|
Medication: meropenem iv loading dose 2000mg, 6000mg continuous per 24 hours +
tobramycine intrathecal 20mg 1dd |
Remarks:
Advies indien de patiënt beschikt over IT toegang. |
|
|
Medication: meropenem iv loading dose 3000mg, 6000mg continuous per 24 hours |
Remarks:
Advies indien de patiënt niet beschikt over IT toegang.
|
| Priority | Medication | Remarks |
|---|---|---|
|
Medication: ceftriaxon iv 2000mg 2dd |
Remarks:
evt. oplaaddosis 2000mg gevolgd door 4000mg/24u continue infusie |
Sources
- SWAB Guideline XVI - Bacteriële CZS infecties
- UMCG Protocol Infecties centraal zenuwstelsel bij volwassenen
-
Pubmed.gov publication # 35862739
Alshaer MH, Barlow B, Maranchick N, Moser M, Gramss L, Burgmann H, Jalali VA, Wölfl-Duchek M, Jäger W, Poschner S, Plöchl W, Reinprecht A, Rössler K, Gruber A, Zeitlinger M, Peloquin CA, Hosmann A. Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0043822. doi: 10.1128/aac.00438-22. Epub 2022 Jul 14. PMID: 35862739; PMCID: PMC9380529.
-
Pubmed.gov publication # 35862757
Kumta N, Heffernan AJ, Cotta MO, Wallis SC, Livermore A, Starr T, Wong WT, Joynt GM, Lipman J, Roberts JA. Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Meropenem in Neurocritical Care Patients: a Prospective Two-Center Study. Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0014222. doi: 10.1128/aac.00142-22. Epub 2022 Jul 6. PMID: 35862757; PMCID: PMC9380572.
Antimicrobial resources
The following antimicrobial agents have been used in these recommendations:
External antimicrobial resources
Menu position
Metadata
Swab vid: G-501389.2
Updated: 04/04/2024 - 12:17
Status: Published
General comments
Antibiotisch beleid aanpassen op geleide van kweekresultaten/gevoeligheid in overleg met arts-microbioloog en/of internist-infectioloog.
Totale behandelduur 21 dagen.