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Community-acquired pneumonie (CAP) - Staphylococcus aureus (non-MRSA)

Advices

≥ 18 years
Priority Medication Remarks
Medication:

flucloxacilline iv loading dose 1000mg, 6000mg continuous per 24 hours 7 to 14 days
Remarks:
Medication:

clindamycine po 600mg 3dd

or

cotrimoxazol (trimethoprim + sulfamethoxazol) po 960mg 2dd

or

doxycycline po loading dose 200mg, 100mg 1dd

or

moxifloxacine po 400mg 1dd
Remarks:
  • Bij iv/po switch.
≥ 18 years

Indications: penicilline allergie
Priority Medication Remarks
Medication:

cefazoline iv loading dose 2000mg, 6000mg continuous per 24 hours 7 to 14 days
Remarks:
  • Bij niet-IgE-gemedieerd (type I) of niet Stevens-Johnson syndroom / TEN.
Remarks:
  • Bij IgE-gemedieerd (type I) of Stevens-Johnson syndroom / TEN: overleg met internist-infectioloog/arts-microbioloog.

General comments

Bij fulminante abcederende necrotiserende Staphylococcus aureus pneumonie: overleg met arts-microbioloog of internist-infectioloog over uitbreiden van de antibiotische therapie t.b.v. toxineremming (zie referenties).

Totale behandelduur 7-14 dagen, afhankelijk van klinische respons.

Sources

  1. Link naar UMCG: CAP protocol
  2. SWAB richtlijn CAP 2024
    View all guidelines
  3. Pubmed.gov publication # 38801783

    Anpalagan K, Dotel R, MacFadden DR, Smith S, Voss L, Petersiel N, Marks M, Marsh J, Mahar RK, McGlothlin A, Lee TC, Goodman A, Morpeth S, Davis JS, Tong SYC, Bowen AC; Adjunctive Clindamycin Domain-Specific Working Group for the Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group. Does Adjunctive Clindamycin Have a Role in Staphylococcus aureus Bacteremia? A Protocol for the Adjunctive Treatment Domain of the Staphylococcus aureus Network Adaptive Platform (SNAP) Randomized Controlled Trial. Clin Infect Dis. 2024 Sep 26;79(3):626-634. doi: 10.1093/cid/ciae289. PMID: 38801783; PMCID: PMC11426255.

  4. van Steen, W.J.; Fliss, M.A.; Metz, E.; Filoda, K.; van den Berg, C.H.S.B.; Sinha, B.; Bathoorn, E. Case Report: Fatal Necrotizing Pneumonia by Exfoliative Toxin etE2-Producing Staphylococcus aureus Belonging to MLST ST152 in The Netherlands. Microorganisms 2025, 13, 1618. https://doi.org/10.3390/microorganisms13071618

Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-211726.8
Updated: 07/22/2025 - 17:09
Status: Published